Interaction of methyl-CpG-binding protein 2 (MeCP2) with distinct enhancers in the mouse cortex

by Clinical Neuropsychologist | Friday, November 22, 2024 | Neuroscience

Nature Neuroscience, Published online: 22 November 2024; doi:10.1038/s41593-024-01808-yThe Rett syndrome protein MeCP2 regulates gene transcription by binding to methylated DNA. Here the authors find that MeCP2 also regulates key neuronal genes by binding to...

Predicting modular functions and neural coding of behavior from a synaptic wiring diagram

by Clinical Neuropsychologist | Friday, November 22, 2024 | Neuroscience

Nature Neuroscience, Published online: 22 November 2024; doi:10.1038/s41593-024-01784-3The authors determine the synaptic wiring diagram of a vertebrate circuit and reveal behaviorally associated modules. A model based on this connectome predicts neural coding and...

The BRAIN initiative: a pioneering program on the precipice

by Clinical Neuropsychologist | Friday, November 22, 2024 | Neuroscience

Nature Neuroscience, Published online: 22 November 2024; doi:10.1038/s41593-024-01811-3Launched in 2013, the BRAIN Initiative (BRAIN) in the United States aimed to unlock the mysteries of the brain and develop new treatments for neurological and neuropsychiatric...

The cell-type underpinnings of the human functional cortical connectome

by Clinical Neuropsychologist | Thursday, November 21, 2024 | Neuroscience

Nature Neuroscience, Published online: 21 November 2024; doi:10.1038/s41593-024-01812-2Here Zhang et al. establish multiscale relationships that link postmortem cell-type distributions with the in vivo functional organization of the human cerebral cortex, as assessed...

Tau filaments are tethered within brain extracellular vesicles in Alzheimer’s disease

by Clinical Neuropsychologist | Thursday, November 21, 2024 | Neuroscience

Nature Neuroscience, Published online: 21 November 2024; doi:10.1038/s41593-024-01801-5Using cryo-electron tomography (cryo-ET) and proteomics, this study identifies the tethering of pathological tau filaments within defined brain extracellular vesicles in Alzheimer’s...

Converging cortical axes

by Clinical Neuropsychologist | Thursday, November 21, 2024 | Neuroscience

Nature Neuroscience, Published online: 21 November 2024; doi:10.1038/s41593-024-01722-3The cerebral cortex shows complex organization across diverse biological scales, from regional chemical and cellular specializations to macroscale functional networks. Zhang et al....