Astrocyte transcriptomic changes along the spatiotemporal progression of Alzheimer’s disease

by Clinical Neuropsychologist | Monday, November 11, 2024 | Neuroscience

Nature Neuroscience, Published online: 11 November 2024; doi:10.1038/s41593-024-01791-4Using single-nucleus RNA sequencing from 32 donors, researchers identified distinct astrocytic gene expression programs activated across brain regions and Alzheimer’s disease...

Endocrine, electrodermal, and cardiac responses to Trier Social Stress Test in healthy adults with a history of child maltreatment.

by Clinical Neuropsychologist | Thursday, November 7, 2024 | Neuroscience

Psychology & Neuroscience, Vol 18(1), Mar 2025, 23-39; doi:10.1037/pne0000353Objective: Exposure to adverse childhood experiences (ACEs) can have long-lasting physiological consequences, including those on the hypothalamic–pituitary–adrenal (HPA) axis regulation....

Construction and content validity of the Brazilian Portuguese Reading and Writing Neuropsychological Instruction program for early grades.

by Clinical Neuropsychologist | Thursday, November 7, 2024 | Neuroscience

Psychology & Neuroscience, Vol 18(1), Mar 2025, 1-22; doi:10.1037/pne0000352Objective: This study describes the construction and evidence of content validity of the Reading and Writing Neuropsychological Instruction program (Instrução Neuropsicológica da Leitura e...

Deep RNA sequencing of human dorsal root ganglion neurons reveals somatosensory mechanisms

by Clinical Neuropsychologist | Wednesday, November 6, 2024 | Neuroscience

Nature Neuroscience, Published online: 06 November 2024; doi:10.1038/s41593-024-01795-0We used single-soma deep RNA sequencing to generate a high-resolution atlas of human somatosensory dorsal root ganglion neurons. This work revealed human-specific molecular...

Spatially resolved gene signatures of white matter lesion progression in multiple sclerosis

by Clinical Neuropsychologist | Tuesday, November 5, 2024 | Neuroscience

Nature Neuroscience, Published online: 05 November 2024; doi:10.1038/s41593-024-01765-6Lesion initiation and progression in multiple sclerosis is a dynamic but unclear process. Here, the authors highlight cell type-specific gene sets characterizing the action lesion...

Cell type mapping reveals tissue niches and interactions in subcortical multiple sclerosis lesions

by Clinical Neuropsychologist | Tuesday, November 5, 2024 | Neuroscience

Nature Neuroscience, Published online: 05 November 2024; doi:10.1038/s41593-024-01796-zLerma-Martin et al. generated a paired single-nucleus RNA sequencing and spatial transcriptomics dataset from subcortical multiple sclerosis lesions, identifying spatial niches and...