Typical development of synaptic and neuronal properties can proceed without microglia in the cortex and thalamus

by Clinical Neuropsychologist | Monday, January 6, 2025 | Neuroscience

Nature Neuroscience, Published online: 06 January 2025; doi:10.1038/s41593-024-01833-xMicroglia are proposed to have a role in brain development through synaptic engulfment and paracrine signaling. O’Keeffe et al. show that certain neurodevelopmental processes...

Monocyte-derived macrophages act as reinforcements when microglia fall short in Alzheimer’s disease

by Clinical Neuropsychologist | Monday, January 6, 2025 | Neuroscience

Nature Neuroscience, Published online: 06 January 2025; doi:10.1038/s41593-024-01847-5This article discusses a puzzling issue in brain pathology: why brain-resident microglia are insufficient for protection, and why myeloid cells are needed from the periphery. Several...

NOMPC ion channel hinge forms a gating spring that initiates mechanosensation

by Clinical Neuropsychologist | Monday, January 6, 2025 | Neuroscience

Nature Neuroscience, Published online: 06 January 2025; doi:10.1038/s41593-024-01849-3Hehlert et al. report that the gating spring that pulls open mechanosensitive NOMPC channels is not their helical ankyrin tether, but instead an elastic hinge that suspends that...

Context-dependent decision-making in the primate hippocampal–prefrontal circuit

by Clinical Neuropsychologist | Monday, January 6, 2025 | Neuroscience

Nature Neuroscience, Published online: 06 January 2025; doi:10.1038/s41593-024-01839-5The brain uses different valuation schemes across contexts. Elston and Wallis show this is supported by hippocampal encoding of context that is broadcast to prefrontal value...

Aberrant splicing in Huntington’s disease accompanies disrupted TDP-43 activity and altered m6A RNA modification

by Clinical Neuropsychologist | Monday, January 6, 2025 | Neuroscience

Nature Neuroscience, Published online: 06 January 2025; doi:10.1038/s41593-024-01850-wNguyen et al. identify TDP-43 and METTL3 as key regulators of disrupted RNA splicing in Huntington’s disease, offering insight into how TDP-43 mislocalization and aberrant m6A RNA...

Multimodal transcriptomics reveal neurogenic aging trajectories and age-related regional inflammation in the dentate gyrus

by Clinical Neuropsychologist | Monday, January 6, 2025 | Neuroscience

Nature Neuroscience, Published online: 06 January 2025; doi:10.1038/s41593-024-01848-4Multimodal transcriptomics unveil the molecular dynamics of neural stem cells and their surrounding niche in the aging mouse hippocampus and provide a resource to understand...