MeCP2 goes into unmethylated territories

by Clinical Neuropsychologist | Tuesday, December 17, 2024 | Neuroscience

Nature Neuroscience, Published online: 17 December 2024; doi:10.1038/s41593-024-01846-6Methyl-CpG-binding protein 2 (MeCP2) is a chromatin regulator whose loss of function causes Rett syndrome. It has been unclear how the gene-expression changes caused by loss of...

Author Correction: Opportunities and challenges of single-cell and spatially resolved genomics methods for neuroscience discovery

by Clinical Neuropsychologist | Monday, December 16, 2024 | Neuroscience

Nature Neuroscience, Published online: 16 December 2024; doi:10.1038/s41593-024-01858-2Author Correction: Opportunities and challenges of single-cell and spatially resolved genomics methods for neuroscience discovery If you do not see content above, kindly GO TO...

Amygdala intercalated cells form an evolutionarily conserved system orchestrating brain networks

by Clinical Neuropsychologist | Friday, December 13, 2024 | Neuroscience

Nature Neuroscience, Published online: 13 December 2024; doi:10.1038/s41593-024-01836-8This comprehensive review of amygdala intercalated cells (ITCs) proposes a revised model of ITCs as a highly coordinated system that integrates diverse inputs to orchestrate...

Simultaneous intracranial recordings of interacting brains reveal neurocognitive dynamics of human cooperation

by Clinical Neuropsychologist | Friday, December 13, 2024 | Neuroscience

Nature Neuroscience, Published online: 13 December 2024; doi:10.1038/s41593-024-01824-yUsing intracranial recordings in pairs of humans cooperating in interactive games, this study shows fine-grained cooperation dynamics featured by state-dependent motives and the...

Author Correction: Dissection of artifactual and confounding glial signatures by single-cell sequencing of mouse and human brain

by Clinical Neuropsychologist | Friday, December 13, 2024 | Neuroscience

Nature Neuroscience, Published online: 13 December 2024; doi:10.1038/s41593-024-01855-5Author Correction: Dissection of artifactual and confounding glial signatures by single-cell sequencing of mouse and human brain If you do not see content above, kindly GO TO...

An RNA editing strategy rescues gene duplication in a mouse model of MECP2 duplication syndrome and nonhuman primates

by Clinical Neuropsychologist | Thursday, December 12, 2024 | Neuroscience

Nature Neuroscience, Published online: 12 December 2024; doi:10.1038/s41593-024-01838-6Duplication of the MECP2 gene (encoding methyl-CpG-binding protein 2) causes MECP2 duplication syndrome. Here the authors develop a Cas13Y system capable of targeting the MECP2 mRNA...