A revised view of the role of CaMKII in learning and memory

by Clinical Neuropsychologist | Monday, November 18, 2024 | Neuroscience

Nature Neuroscience, Published online: 18 November 2024; doi:10.1038/s41593-024-01809-xThe CaMKII holoenzyme was long thought to mediate memory storage via an autophosphorylation reaction that occurs between its subunits at Thr286 (pThr286). This Perspective explains...

Emergence of a brainstem somatosensory tonotopic map for substrate vibration

by Clinical Neuropsychologist | Friday, November 15, 2024 | Neuroscience

Nature Neuroscience, Published online: 15 November 2024; doi:10.1038/s41593-024-01821-1Lee et al. show that the development of the somatotopic map and the tonotopic map for substrate vibration is shaped by the intrinsic distribution of cutaneous end organs and...

Multimodal evaluation of network activity and optogenetic interventions in human hippocampal slices

by Clinical Neuropsychologist | Friday, November 15, 2024 | Neuroscience

Nature Neuroscience, Published online: 15 November 2024; doi:10.1038/s41593-024-01782-5Brain slices offer an experimental window into human neurophysiology. Using high-density microelectrode array recordings and adeno-associated virus–mediated optogenetics, the...

Orbitofrontal Cortex Mediates Sustained Basolateral Amygdala Encoding of Cued Reward-Seeking States

by Clinical Neuropsychologist | Thursday, November 14, 2024 | Neuroscience

Basolateral amygdala (BLA) neurons are engaged by emotionally salient stimuli. An area of increasing interest is how BLA dynamics relate to evolving reward-seeking behavior, especially under situations of uncertainty or ambiguity. Here, we recorded the activity of...

TYK2 regulates tau levels, phosphorylation and aggregation in a tauopathy mouse model

by Clinical Neuropsychologist | Monday, November 11, 2024 | Neuroscience

Nature Neuroscience, Published online: 11 November 2024; doi:10.1038/s41593-024-01777-2Tyrosine kinase 2 (TYK2) critically regulates tau levels and aggregation by phosphorylating tau’s tyrosine 29. Partial inhibition of TYK2 mitigates tau pathologies in cells and...

Astrocyte transcriptomic changes along the spatiotemporal progression of Alzheimer’s disease

by Clinical Neuropsychologist | Monday, November 11, 2024 | Neuroscience

Nature Neuroscience, Published online: 11 November 2024; doi:10.1038/s41593-024-01791-4Using single-nucleus RNA sequencing from 32 donors, researchers identified distinct astrocytic gene expression programs activated across brain regions and Alzheimer’s disease...