Magnetic resonance microscopy maps widespread effects of Alzheimer’s disease on brain structures and behavior in mice

by Clinical Neuropsychologist Online | Thursday, February 26, 2026 | Neuroscience

Nature Neuroscience, Published online: 26 February 2026; doi:10.1038/s41593-025-02199-4Alzheimer’s disease alters brain structure broadly, but its regional impact is poorly mapped. Here, the authors show that App and Psen1 mutations in mice cause volume changes across...

Functional bipartite invariance in mouse primary visual cortex receptive fields

by Clinical Neuropsychologist Online | Wednesday, February 25, 2026 | Neuroscience

Nature Neuroscience, Published online: 25 February 2026; doi:10.1038/s41593-026-02213-3This study uses the inception loop framework to map neuronal invariances in mouse V1, revealing a bipartite receptive-field organization linked to segmentation and a synaptic-level...

Orbitofrontal cortex drives predictive filtering of sensory responses

by Clinical Neuropsychologist Online | Tuesday, February 24, 2026 | Neuroscience

Nature Neuroscience, Published online: 24 February 2026; doi:10.1038/s41593-026-02217-zTop-down projections from the orbitofrontal cortex carry predictive signals that grow with sound experience and suppress the auditory cortex via inhibitory circuits, revealing a...

Convolutional neural network models describe the encoding subspace of local circuits in auditory cortex

by Clinical Neuropsychologist Online | Monday, February 23, 2026 | Neuroscience

Nature Neuroscience, Published online: 23 February 2026; doi:10.1038/s41593-026-02216-0Wingert, Parida and colleagues measured tuning subspaces from deep-learning models trained on single neurons in auditory cortex. They show that subspaces distinguish functional...

Behavioral timescale synaptic plasticity: properties, elements and functions

by Clinical Neuropsychologist Online | Friday, February 20, 2026 | Neuroscience

Nature Neuroscience, Published online: 20 February 2026; doi:10.1038/s41593-026-02214-2Understanding how brains learn and remember remains among the most important challenges in science. Recent studies suggest that a new form of synaptic plasticity provides a basis...

Autoimmune neuroinflammation leads to neuronal death via MIF nuclease-mediated parthanatos

by Clinical Neuropsychologist Online | Tuesday, February 17, 2026 | Neuroscience

Nature Neuroscience, Published online: 17 February 2026; doi:10.1038/s41593-026-02201-7Neuroinflammation triggers DNA damage and subsequent parthanatos-mediated neuron death. Inhibiting parthanatos in a mouse model of autoimmune inflammation is neuroprotective and...