A brainstem pathway underlying vagal modulation of somatic pain and affective states

by Clinical Neuropsychologist Online | Wednesday, June 3, 2026 | Neuroscience

Nature Neuroscience, Published online: 03 June 2026; doi:10.1038/s41593-026-02313-0This study identifies a brainstem pathway through which vagus nerve stimulation reduces pain and negative affect, showing how the caudal nucleus of the solitary tract transforms pain...

The representational geometry of emotional states in basolateral amygdala

by Clinical Neuropsychologist Online | Wednesday, June 3, 2026 | Neuroscience

Nature Neuroscience, Published online: 03 June 2026; doi:10.1038/s41593-026-02315-yO’Neill, Posani and colleagues show that while single amygdala neurons encode multiple emotional state-related variables (for example, valence, fear and safety), population-level...

Single-cell multi-omic atlas and morphogen screening informs midbrain and hindbrain organoid engineering

by Clinical Neuropsychologist Online | Wednesday, June 3, 2026 | Neuroscience

Nature Neuroscience, Published online: 03 June 2026; doi:10.1038/s41593-026-02316-xBy combining single-cell sequencing and morphogen screening, researchers map how signaling cues shape cell identity in mid-hindbrain organoids and identify conditions that generate...

Microbial reactivation of host androgens directs enteric neuronal regulation of gut motility

by Clinical Neuropsychologist Online | Tuesday, June 2, 2026 | Neuroscience

Nature Neuroscience, Published online: 02 June 2026; doi:10.1038/s41593-026-02321-0This study shows that androgens signal to specific enteric neurons to stimulate gut motility. Bacterial metabolism of host-derived steroids generates the ligands, revealing a dynamic...

Deep brain stimulation induces white matter remodeling and functional changes to brain-wide networks

by Clinical Neuropsychologist Online | Monday, June 1, 2026 | Neuroscience

Nature Neuroscience, Published online: 01 June 2026; doi:10.1038/s41593-026-02301-4In a nonhuman primate model, Fujimoto et al. show that deep brain stimulation promotes white matter remodeling and reorganizes brain-wide functional networks, detailing a mechanism...

Why pain biomarkers cannot replace the patient experience

by Clinical Neuropsychologist Online | Monday, June 1, 2026 | Neuroscience

Nature Neuroscience, Published online: 01 June 2026; doi:10.1038/s41593-026-02324-xUsing neuroimaging to understand the mechanisms of pain is an important task. But we must understand that the gold standard of measuring pain will always be the self-report. If you do...