Synaptic plasticity rules driving representational shifting in the hippocampus

by Clinical Neuropsychologist Online | Thursday, March 20, 2025 | Neuroscience

Nature Neuroscience, Published online: 20 March 2025; doi:10.1038/s41593-025-01894-6Madar et al. report that behavioral timescale synaptic plasticity (BTSP), not spike-timing-dependent plasticity, explains heterogeneous place fields shifting in the hippocampus. The...

Cancer research needs neuroscience and neuroscientists

by Clinical Neuropsychologist Online | Thursday, March 20, 2025 | Neuroscience

Nature Neuroscience, Published online: 20 March 2025; doi:10.1038/s41593-025-01925-2The nervous system can drive the initiation, growth, spread, and therapy resistance of cancer, and cancer can manipulate the nervous system in ways that further support disease...

Prospective contingency explains behavior and dopamine signals during associative learning

by Clinical Neuropsychologist Online | Tuesday, March 18, 2025 | Neuroscience

Nature Neuroscience, Published online: 18 March 2025; doi:10.1038/s41593-025-01915-4The authors show that behavior and dopamine responses track prospective, but not retrospective, contingency. These results are explained by temporal difference (TD) learning models,...

Lewy body disease can spread via two distinct body-first routes

by Clinical Neuropsychologist Online | Tuesday, March 18, 2025 | Neuroscience

Nature Neuroscience, Published online: 18 March 2025; doi:10.1038/s41593-025-01911-8Lewy body disease (LBD) pathology can first spread from the brain or the body. A study of two large postmortem datasets reveals that there are not one but two possible trajectories...

Composing hippocampal maps from cortical building blocks in replay

by Clinical Neuropsychologist Online | Tuesday, March 18, 2025 | Neuroscience

Nature Neuroscience, Published online: 18 March 2025; doi:10.1038/s41593-025-01909-2We modeled how the hippocampus can construct new cognitive maps from reusable building blocks (structural elements) represented in cortex. This composition supported latent learning...

Endothelial TDP-43 depletion disrupts core blood–brain barrier pathways in neurodegeneration

by Clinical Neuropsychologist Online | Friday, March 14, 2025 | Neuroscience

Nature Neuroscience, Published online: 14 March 2025; doi:10.1038/s41593-025-01914-5Targeting the endothelium across ages and neurodegenerative diseases in 92 donors with single-cell inCITE-seq reveals similar alterations in ~40% of capillaries in AD, ALS and FTD....