Abstract
BACKGROUND
We describe the Alzheimer’s Disease Neuroimaging Initiative (ADNI) Biomarker Core major activities from October 2004 to March 2024, including biobanking ADNI cerebrospinal fluid (CSF), plasma, and serum biofluid samples, biofluid analyses for Alzheimer’s disease (AD) biomarkers in the Biomarker Core and various non-ADNI laboratories, and continuous assessments of pre-analytics.
RESULTS
Validated immunoassay and mass spectrometry-based assays were performed in CSF with a shift to plasma, a more accessible biofluid, as qualified assays became available. Performance comparisons across different CSF and plasma AD biomarker measurement platforms have enriched substantially the ADNI participant database enabling method performance determinations for AD pathology detection and longitudinal assessments of disease progression.
DISCUSSION
Close collaboration with academic and industrial partners in the validation and implementation of AD biomarkers for early detection of disease pathology in treatment trials and ultimately in clinical practice is a key factor for the success of the work done in the Biomarker Core.
Highlights
Describe ADNI Biomarker Core biobanking and sample distribution from 2007 to 2024.
Discuss validated mass spectrometry and immunoassay methods for ADNI biofluid analyses.
Review collaborations with academic and industrial partners to detect AD and progression.
Discuss major challenges, and progress to date, for co-pathology detection.
Implementation in the ATN scheme: co-pathology and modeling disease progression.
If you do not see content above, kindly GO TO SOURCE.
Not all publishers encode content in a way that enables republishing at Neuro.vip.
This post is Copyright: Leslie M. Shaw,
Magdalena Korecka,
Edward B. Lee,
Katheryn A Q Cousins,
Hugo Vanderstichele,
Suzanne E. Schindler,
Duygu Tosun,
Mari L. DeMarco,
Magdalena Brylska,
Yang Wan,
Samantha Burnham,
Alexandria Sciulli,
Amberley Vulaj,
Thomas F. Tropea,
Alice Chen‐Plotkin,
David A. Wolk,
the Alzheimer’s Disease Neuroimaging Initiative | November 30, 2024