Abstract
INTRODUCTION
While there may be microbial contributions to Alzheimer’s disease (AD), findings have been inconclusive. We recently reported an AD-associated CD83(+) microglia subtype associated with increased immunoglobulin G4 (IgG4) in the transverse colon (TC).
METHODS
We used immunohistochemistry (IHC), IgG4 repertoire profiling, and brain organoid experiments to explore this association.
RESULTS
CD83(+) microglia in the superior frontal gyrus (SFG) are associated with elevated IgG4 and human cytomegalovirus (HCMV) in the TC, anti-HCMV IgG4 in cerebrospinal fluid, and both HCMV and IgG4 in the SFG and vagal nerve. This association was replicated in an independent AD cohort. HCMV-infected cerebral organoids showed accelerated AD pathophysiological features (Aβ42 and pTau-212) and neuronal death.
DISCUSSION
Findings indicate complex, cross-tissue interactions between HCMV and the adaptive immune response associated with CD83(+) microglia in persons with AD. This may indicate an opportunity for antiviral therapy in persons with AD and biomarker evidence of HCMV, IgG4, or CD83(+) microglia.
Highlights
Cross-tissue interaction between HCMV and the adaptive immune response in a subset of persons with AD.
Presence of CD83(+) microglial associated with IgG4 and HCMV in the gut.
CD83(+) microglia are also associated presence of HCMV and IgG4 in the cortex and vagal nerve.
Replication of key association in an independent cohort of AD subjects.
HCMV infection of cerebral organoids accelerates the production of AD neuropathological features.
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This post is Copyright: Benjamin P. Readhead,
Diego F. Mastroeni,
Qi Wang,
Maria A. Sierra,
Camila de Ávila,
Tajudeen O. Jimoh,
Jean‐Vianney Haure‐Mirande,
Kristina E. Atanasoff,
Jennifer Nolz,
Crystal Suazo,
Nathaniel J. Barton,
Adrian R. Orszulak,
Samantha M. Chigas,
Khanh Tran,
Anne Mirza,
Krista Ryon,
Jacqueline Proszynski,
Deena Najjar,
Joel T. Dudley,
Sean T. H. Liu,
Sam Gandy,
Michelle E. Ehrlich,
Eric Alsop,
Jerry Antone,
Rebecca Reiman,
Cory Funk,
Rebecca L. Best,
Michael Jhatro,
Kathy Kamath,
John Shon,
Timothy F. Kowalik,
David A. Bennett,
Winnie S. Liang,
Geidy E. Serrano,
Thomas G. Beach,
Kendall Van Keuren‐Jensen,
Christopher E. Mason,
Yingleong Chan,
Elaine T. Lim,
Domenico Tortorella,
Eric M. Reiman | December 19, 2024