Alzheimer’s disease (AD) is characterized by cognitive impairments; however, heightened anxiety often accompanies and, in some cases, exacerbates cognitive its. The present study aims to understand the influence of multiple variables on anxiety-like behavior in TgF344-AD rats and determine whether anxiety impacts memory performance.
An elevated plus maze was used to assess anxiety-like behavior in the established colony (n = 107). Influences of age, sex, genotype, and exercise on anxiety were evaluated via multiple linear regression. Correlation analysis evaluated the relationship between anxiety and memory performance.
Age (P < 0.05) and AD genotype (P < 0.001) were associated with increasing anxiety, while exercise (P < 0.05) was associated with decreasing anxiety. Female AD animals displayed more anxiety-like behavior versus wild-type female (P < 0.001) and AD male (P < 0.05) littermates.
Concluding that while factors such as age, sex, AD genotype, and training status can impact anxiety levels in the TgF344-AD model, anxiety level did not impact memory performance.

Increased anxiety-like behavior in TgF344-AD rats does not correlate with declines in memory performance.
Predictors of higher anxiety-like behaviors in the TgF344-AD rat include age, Alzheimer’s disease (AD) genotype, and sex with female AD animals experiencing greater anxiety compared to female wild-type or male AD.
Exercise training leads to decreased anxiety-like behaviors in the TgF344-AD rat.

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This post is Copyright: Danielle C. Lopez,
Zachary J. White,
Stephanie E. Hall | April 16, 2024

Wiley: Alzheimer’s & Dementia: Table of Contents