Abstract
BACKGROUND
Limited research has explored the effect of cardiovascular risk and amyloid interplay on cognitive decline in East Asians.
METHODS
Vascular burden was quantified using Framingham’s General Cardiovascular Risk Score (FRS) in 526 Korean Brain Aging Study (KBASE) participants. Cognitive differences in groups stratified by FRS and amyloid positivity were assessed at baseline and longitudinally.
RESULTS
Baseline analyses revealed that amyloid-negative (Aβ–) cognitively normal (CN) individuals with high FRS had lower cognition compared to Aβ– CN individuals with low FRS (p < 0.0001). Longitudinally, amyloid pathology predominantly drove cognitive decline, while FRS alone had negligible effects on cognition in CN and mild cognitive impairment (MCI) groups.
CONCLUSION
Our findings indicate that managing vascular risk may be crucial in preserving cognition in Aβ– individuals early on and before the clinical manifestation of dementia. Within the CN and MCI groups, irrespective of FRS status, amyloid-positive individuals had worse cognitive performance than Aβ– individuals.
Highlights
Vascular risk significantly affects cognition in amyloid-negative older Koreans.
Amyloid-negative CN older adults with high vascular risk had lower baseline cognition.
Amyloid pathology drives cognitive decline in CN and MCI, regardless of vascular risk.
The study underscores the impact of vascular health on the AD disease spectrum.
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This post is Copyright: Soumilee Chaudhuri,
Desarae A. Dempsey,
Yen‐Ning Huang,
Tamina Park,
Sha Cao,
Evgeny J. Chumin,
Hannah Craft,
Paul K. Crane,
Shubhabrata Mukherjee,
Seo‐Eun Choi,
Phoebe Scollard,
Michael Lee,
Connie Nakano,
Jesse Mez,
Emily H. Trittschuh,
Brandon S. Klinedinst,
Timothy J. Hohman,
Jun‐Young Lee,
Koung Mi Kang,
Chul‐Ho Sohn,
Yu Kyeong Kim,
Dahyun Yi,
Min Soo Byun,
Shannon L. Risacher,
Kwangsik Nho,
Andrew J. Saykin,
Dong Young Lee,
for the KBASE Research Group | November 8, 2024