Abstract
INTRODUCTION
Evaluating whether genetic susceptibility modifies the impact of lifestyle-related factors on dementia is critical for prevention.
METHODS
We studied 5170 participants from a French cohort of older persons free of dementia at baseline and followed for up to 17 years. The LIfestyle for BRAin health risk score (LIBRA) including 12 modifiable factors was constructed at baseline (higher score indicating greater risk) and was related to both subsequent cognitive decline and dementia incidence, according to genetic susceptibility to dementia (reflected by the apolipoprotein E [APOE] ε4 allele and a genetic risk score [GRS]).
RESULTS
The LIBRA was associated with higher dementia incidence, with no significant effect modification by genetics (hazard ratio for one point score = 1.09 [95% confidence interval, 1.05; 1.13]) in APOE ε4 non-carriers and = 1.15 [1.08; 1.22] in carriers; P = 0.15 for interaction). Similar findings were obtained with the GRS and with cognitive decline.
DISCUSSION
Lifestyle-based prevention may be effective whatever the genetic susceptibility to dementia.
If you do not see content above, kindly GO TO SOURCE.
Not all publishers encode content in a way that enables republishing at Neuro.vip.
This post is Copyright: Jeanne Neuffer,
Maude Wagner,
Elisa Moreno,
Quentin Le Grand,
Aniket Mishra,
David‐Alexandre Trégouët,
Karen Leffondre,
Cécile Proust‐Lima,
Alexandra Foubert‐Samier,
Claudine Berr,
Christophe Tzourio,
Catherine Helmer,
Stéphanie Debette,
Cécilia Samieri | May 22, 2024