Abstract
INTRODUCTION
We examined the associations of polygenic risk score (PRS) with Alzheimer’s disease (AD) and plasma biomarkers in the Chinese population.
METHODS
This population-based study used baseline data from MIND-China (2018; n = 4873) and follow-up data from dementia-free individuals (2014–2018; n = 2117). We measured AD-related plasma biomarkers in a subsample (n = 1256). Data were analyzed using logistic and Cox regression models.
RESULTS
We developed PRS with (PRS
APOE
) and without (PRSnon-
APOE
) apolipoprotein E (APOE) gene. In the longitudinal analysis, PRS
APOE
was associated with a multivariable-adjusted hazards ratio of 1.91 (95% CI = 1.13–3.23) for AD. PRS
APOE
in combination with demographics yielded discriminative (area under the curve [AUC]) and predictive(C-statistic) accuracy of 0.80 (95% confidence interval [CI] = 0.77–0.84) and 0.80 (0.77–0.82), respectively. PRSnon-
APOE
showed an association with AD risk similar to PRS
APOE
. PRS
APOE
, but not PRSnon-
APOE
, was associated with reduced plasma Aβ42/Aβ40 ratio and increased Neurofilament light chain (NfL) (p < 0.05).
DISCUSSION
The PRS with and without APOE gene, in combination with demographics, shows good discriminative and predictive ability for AD. The AD-related pathologies underlie AD risk associated with PRS
APOE
.
Highlights
The PRS
APOE
and PRSnon-
APOE
were associated with AD risk in the Chinese population.
The PRS
APOE
and PRSnon-
APOE
, in combination with demographics, showed good discriminative and predictive ability for AD.
The AD-related pathologies underlie the AD risk associated with PRS
APOE
but not PRSnon-
APOE
.
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This post is Copyright: Tingting Hou,
Keke Liu,
Wenxin Fa,
Cuicui Liu,
Min Zhu,
Xiaoyan Liang,
Yifei Ren,
Shan Xu,
Xiang Wang,
Shi Tang,
Yongxiang Wang,
Lin Cong,
Qihuan Tan,
Yifeng Du,
Chengxuan Qiu | August 22, 2024