Abstract
INTRODUCTION
Type 1 diabetes mellitus (T1DM) increases dementia risk. Understanding clinical modifiers of that effect could inform prevention.
METHODS
We analyzed data from All of Us. Participants were aged ≥50 years with T1DM (n = 5,442) or no diabetes (n = 226,819).
RESULTS
Among 232,261 participants (mean [SD] age 64.5 [9.0] years; 57.3% women), 2.3% had a T1DM diagnosis. Among those without diabetes, each additional comorbidity corresponded to a dementia hazard ratio (HR) of 1.22 (95% CI: 1.19, 1.26). The dementia HR among participants with both T1DM and depression, compared with having neither, was pronounced (HR: 5.47 [95% CI: 4.23, 7.08]) and consistent with the independent associations of T1DM alone (HR: 2.01 [95% CI:1.38, 2.92]) and depression alone (HR: 2.55 [95% CI: 2.22, 2.95]).
DISCUSSION
Individuals who have both T1DM and depression are at especially high risk for dementia.
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This post is Copyright: | September 21, 2026
Neuro-Dementia