Abstract
INTRODUCTION
Using an Asian cohort with high prevalence of concomitant cerebrovascular disease (CeVD), we evaluated the performance of a plasma immunoassay for tau phosphorylated at threonine 217 (p-tau217) in detecting amyloid beta positivity (Aβ+) on positron emission tomography and cognitive decline, based on a three-range reference, which stratified patients into low-, intermediate-, and high-risk groups for Aβ+.
METHODS
Brain amyloid status (Aβ– [n = 142] vs Aβ+ [n = 73]) on amyloid PET scans was assessed along with the plasma ALZpath p-tau217 assay to derive three-range reference points for PET Aβ+ based on 90% sensitivity (lower threshold) and 90% specificity (upper threshold).
RESULTS
Plasma p-tau217 (area under the curve [AUC] = 0.923) outperformed routine clinical assessments (AUC = 0.760–0.819; p ≤ 0.003) and other plasma biomarkers (AUC = 0.817–0.834; p < 0.001). The high-risk group showed significantly higher rates of cognitive decline than the low-risk group.
DISCUSSION
Risk stratification for PET Aβ+ based on a plasma p-tau217 assay demonstrated potential diagnostic and prognostic utility in an Asian cohort with concomitant CeVD.
Highlights
The utility of plasma p-tau217 to detect brain amyloid beta pathology (Aβ+) was studied in an Asian cohort with concomitant cerebrovascular disease
Plasma tau phosphorylated at threonine 217 (p-tau217) showed superior utility in detecting Aβ+ compared to neuroimaging measures, clinical workup, or other blood biomarkers including p-tau181, glial fibrillary protein (GFAP), and Aβ
Higher plasma p-tau217 correlated with faster cognitive decline
Plasma p-tau217 shows promise as an Alzheimer’s disease (AD) diagnostic and prognostic biomarker in diverse populations
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This post is Copyright: Joyce R. Chong,
Saima Hilal,
Boon Yeow Tan,
Narayanaswamy Venketasubramanian,
Michael Schöll,
Henrik Zetterberg,
Kaj Blennow,
Nicholas J. Ashton,
Christopher P. Chen,
Mitchell K. P. Lai | January 14, 2025