Individuals referred to as Non-Demented with Alzheimer’s Neuropathology (NDAN) exhibit cognitive resilience despite presenting Alzheimer’s disease (AD) histopathological signs. Investigating the mechanisms behind this resilience may unveil crucial insights into AD resistance.
DiI labeling technique was used to analyze dendritic spine morphology in control (CTRL), AD, and NDAN post mortem frontal cortex, particularly focusing on spine types near and far from amyloid beta (Aβ) plaques.
NDAN subjects displayed a higher spine density in regions distant from Aβ plaques versus AD patients. In distal areas from the plaques, NDAN individuals exhibited more immature spines, while AD patients had a prevalence of mature spines. Additionally, our examination of levels of Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (Pin1), a protein associated with synaptic plasticity and AD, showed significantly lower expression in AD versus NDAN and CTRL.
These results suggest that NDAN individuals undergo synaptic remodeling, potentially facilitated by Pin1, serving as a compensatory mechanism to preserve cognitive function despite AD pathology.

Spine density is reduced near Aβ plaques compared to the distal area in CTRL, AD, and NDAN dendrites.
NDAN shows higher spine density than AD in areas far from Aβ plaques.
Far from Aβ plaques, NDAN has a higher density of immature spines, AD a higher density of mature spines.
AD individuals show significantly lower levels of Pin1 compared to NDAN and CTRL.

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This post is Copyright: Jutatip Guptarak,
Pietro Scaduto,
Batbayar Tumurbaatar,
Wen Ru Zhang,
Daniel Jupiter,
Giulio Taglialatela,
Anna Fracassi | June 3, 2024

Wiley: Alzheimer’s & Dementia: Table of Contents