Abstract
BACKGROUND
Metabolic dysregulation is a hallmark of neurodegenerative diseases, including Alzheimer’s disease (AD) and progressive supranuclear palsy (PSP). Although metabolic dysregulation is a common link between these two tauopathies, a comprehensive brain metabolic comparison of the diseases has not yet been performed.
METHODS
We analyzed 342 postmortem brain samples from the Mayo Clinic Brain Bank and examined 658 metabolites in the cerebellar cortex and the temporal cortex between the two tauopathies.
RESULTS
Our findings indicate that both diseases display oxidative stress associated with lipid metabolism, mitochondrial dysfunction linked to lysine metabolism, and an indication of tau-induced polyamine stress response. However, specific to AD, we detected glutathione-related neuroinflammation, deregulations of enzymes tied to purines, and cognitive deficits associated with vitamin B.
DISCUSSION
Our findings underscore vast alterations in the brain’s metabolome, illuminating shared neurodegenerative pathways and disease-specific traits in AD and PSP.
Highlights
First high-throughput metabolic comparison of Alzheimer’s diesease (AD) versus progressive supranuclear palsy (PSP) in brain tissue.
Cerebellar cortex (CER) shows substantial AD-related metabolic changes, despite limited proteinopathy.
AD impacts both CER and temporal cortex (TCX); PSP’s changes are primarily in CER.
AD and PSP share metabolic alterations despite major pathological differences.
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This post is Copyright: Richa Batra,
Jan Krumsiek,
Xue Wang,
Mariet Allen,
Colette Blach,
Gabi Kastenmüller,
Matthias Arnold,
Nilüfer Ertekin‐Taner,
Rima Kaddurah‐Daouk,
for the Alzheimer’s Disease Metabolomics Consortium (ADMC) | October 23, 2024