Abstract
BACKGROUND
Cortical microinfarcts (CMI) were attributed to cerebrovascular disease and cerebral amyloid angiopathy (CAA). CAA is frequent in Down syndrome (DS) while hypertension is rare, yet no studies have assessed CMI in DS.
METHODS
We included 195 adults with DS, 63 with symptomatic sporadic Alzheimer’s disease (AD), and 106 controls with 3T magnetic resonance imaging. We assessed CMI prevalence in each group and CMI association with age, AD clinical continuum, vascular risk factors, vascular neuroimaging findings, amyloid/tau/neurodegeneration biomarkers, and cognition in DS.
RESULTS
CMI prevalence was 11.8% in DS, 4.7% in controls, and 17.5% in sporadic AD. In DS, CMI increased in prevalence with age and the AD clinical continuum, was clustered in the parietal lobes, and was associated with lacunes and cortico-subcortical infarcts, but not hemorrhagic lesions.
DISCUSSION
In DS, CMI are posteriorly distributed and related to ischemic but not hemorrhagic findings suggesting they might be associated with a specific ischemic CAA phenotype.
Highlights
This is the first study to assess cortical microinfarcts (assessed with 3T magnetic resonance imaging) in adults with Down syndrome (DS).
We studied the prevalence of cortical microinfarcts in DS and its relationship with age, the Alzheimer’s disease (AD) clinical continuum, vascular risk factors, vascular neuroimaging findings, amyloid/tau/neurodegeneration biomarkers, and cognition.
The prevalence of cortical microinfarcts was 11.8% in DS and increased with age and along the AD clinical continuum. Cortical microinfarcts were clustered in the parietal lobes, and were associated with lacunes and cortico-subcortical infarcts, but not hemorrhagic lesions.
In DS, cortical microinfarcts are posteriorly distributed and related to ischemic but not hemorrhagic findings suggesting they might be associated with a specific ischemic phenotype of cerebral amyloid angiopathy.
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This post is Copyright: Mateus Rozalem Aranha,
Victor Montal,
Hilde van den Brink,
Jordi Pegueroles,
Maria Carmona‐Iragui,
Laura Videla,
Lucia Maure Blesa,
Bessy Benejam,
Javier Arranz,
Sílvia Valldeneu,
Isabel Barroeta,
Susana Fernández,
Laia Ribas,
Daniel Alcolea,
Sofía González‐Ortiz,
Núria Bargalló,
Geert Jan Biessels,
Rafael Blesa,
Alberto Lleó,
Artur Martins Coutinho,
Cláudia Costa Leite,
Alexandre Bejanin,
Juan Fortea | April 22, 2024