Abstract
INTRODUCTION
The prognostic value of emerging dementia-related blood-based biomarkers for post-stroke cognitive impairment is poorly understood. We addressed this critical gap in this systematic review.
METHODS
Four databases were searched in March 2025 for studies of neurofilament light (NfL), glial fibrillary acidic protein (GFAP), amyloid beta (Aβ), tau, and placental growth factor (PlGF) in relation to post-stroke cognitive outcomes. Risk of bias, narrative synthesis, and meta-analysis were performed.
RESULTS
Eighteen studies were included, eleven assessing NfL. Meta-analysis of four studies (n = 2020) showed higher acute NfL was associated with worse cognition at 1–6 months (Z = −0.518, 95% confidence interval [CI] −0.684 to −0.351). Baseline GFAP was associated with worse cognition longitudinally, whereas results for amyloid and tau species were inconsistent between studies. Risk of bias was high.
DISCUSSION
NfL and GFAP show the most consistent associations with post-stroke cognition, particularly acutely. Evidence for amyloid and tau was inconsistent between studies, and PlGF remains unexplored.
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This post is Copyright: | July 7, 2026
Neuro-Dementia