Abstract
INTRODUCTION
There is limited knowledge about early-onset dementia (EOD) on fracture risk.
METHODS
Individuals ages 50 to 64 were identified from the National Database of Health Insurance Claims and Specific Health Checkups of Japan (2012 to 2019). The association between EOD and fractures and the association between cholinesterase inhibitors for EOD and fractures were evaluated using logistic regression analyses.
RESULTS
We identified 13,614 EOD patients and 9,144,560 cognitively healthy individuals. The analysis revealed that EOD was associated with an increased risk of hip fractures (adjusted odds ratio, 95% confidence interval: 8.79, 7.37–10.48), vertebral fractures (1.73, 1.48–2.01), and major osteoporotic fractures (2.05, 1.83–2.30) over 3 years. The use of cholinesterase inhibitors was significantly associated with a reduction in hip fractures among EOD patients (0.28, 0.11–0.69).
DISCUSSION
EOD patients have a higher risk of osteoporotic fractures than cognitively healthy individuals. The use of cholinesterase inhibitors may reduce the risk of hip fracture among EOD patients.
Highlights
It is unknown whether early-onset dementia (EOD) increases the risk of fractures.
We identified 13,614 individuals with EOD using a nationwide administrative database.
Patients with EOD have a higher risk of hip, vertebral, and major osteoporotic fractures.
The use of cholinesterase inhibitors may reduce hip fracture among patients with EOD.
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This post is Copyright: Shoya Matsumoto,
Tatsuya Hosoi,
Mitsutaka Yakabe,
Kenji Fujimori,
Junko Tamaki,
Shinichi Nakatoh,
Shigeyuki Ishii,
Nobukazu Okimoto,
Masahiro Akishita,
Masayuki Iki,
Sumito Ogawa | April 2, 2024