Abstract
BACKGROUND
The study aim is to investigate whether blood biomarkers (BBMs) of Alzheimer’s disease (AD) pathology are associated with postoperative cognitive dysfunction (POCD) after cardiac surgery.
METHODS
Cognitive performance was assessed before and 12 months postoperatively using the Montreal Cognitive Assessment (MoCA) and categorized into stages—minimal (1), notable (2), and substantial (3) decline—in the FIND DElirium RIsk factors (FINDERI) study of patients undergoing cardiac surgery. BBMs were measured preoperatively (amyloid beta [Aβ]1-42, Aβ1-40, phosphorylated tau 181 [p-tau181], p-tau217, apolipoprotein E ε4 [apoE4] and apoE).
RESULTS
A total of 394 patients completed follow-up investigations. POCD Stage 1 was observed in 105 (26.6%), POCD Stage 2 in 52 patients (13.2%), and POCD Stage 3 in 30 patients (7.6%). The AT217term (ratio Aβ1-40/1-42 * p-tau217) was significantly associated with POCD stages in multiple logistic regression.
DISCUSSION
Early Alzheimer’s BBMs are associated with POCD in patients, suggesting that our exploratory findings assessing BBMs may support risk stratification, inform decision-making, and contribute to strategies aimed at preventing POCD.
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This post is Copyright: | July 14, 2026
Neuro-Dementia