Abstract
INTRODUCTION
Women with early bilateral salpingo-oophorectomy (BSO) have greater Alzheimer’s disease (AD) risk than women with spontaneous menopause (SM), but the pathway toward this risk is understudied. Considering associative memory deficits may reflect early signs of AD, we studied how BSO affected brain activity underlying associative memory.
METHODS
Early midlife women with BSO (with and without 17β-estradiol therapy [ET]) and age-matched controls (AMCs) with intact ovaries completed a face–name associative memory task during functional magnetic resonance imaging. Hippocampal activity along the anteroposterior axis during associative encoding and retrieval was compared among three groups (BSO [n = 28], BSO+ET [n = 35], AMCs [n = 40]).
RESULTS
Both BSO groups (with and without ET) showed lower posterior hippocampal activation during encoding compared to the AMC group. However, this difference in activation was not significantly correlated with associative memory task performance.
DISCUSSION
Early 17β-estradiol loss may influence posterior hippocampal activity during associative encoding, possibly presaging late-life AD.
Highlights
After ovarian removal, changes in hippocampal function may affect dementia risk.
Midlife ovarian removal is associated with less activation in the posterior hippocampus.
Estradiol therapy may ameliorate alterations in brain function during learning.
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This post is Copyright: Alana Brown,
Laura Gravelsins,
Nicole J. Gervais,
Jenny Rieck,
Sophia Zhao,
Annie Duchesne,
Suzanne T. Witt,
Robin Kämpe,
Rosanna Olsen,
Morgan Barense,
Elisabet Classon,
Elvar Theodorsson,
Jan Ernerudh,
Elisabeth Åvall‐Lundqvist,
Preben Kjølhede,
Maria Engström,
Zhuo Shao,
Marcus Bernardini,
Michelle Jacobson,
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Cheryl Grady,
Gillian Einstein | December 29, 2024