This study delineated the interrelationships between subclinical alterations in the left heart, cerebrospinal fluid (CSF), Alzheimer’s disease (AD) biomarkers, and cognition.
Multiple linear regressions were conducted in 1244 cognitively normal participants (mean age = 65.5; 43% female) who underwent echocardiography (left atrial [LA] and left ventricular [LV] morphologic or functional parameters) and CSF AD biomarkers measurements. Mediating effects of AD pathologies were examined. Differences in cardiac parameters across ATN categories were tested using analysis of variance (ANOVA) and logistic regressions.
LA or LV enlargement (characterized by increased diameters and volumes) and LV hypertrophy (increased interventricular septal or posterior wall thickness and ventricular mass) were associated with higher CSF phosphorylated (p)-tau and total (t)-tau levels, and poorer cognition. Tau pathologies mediated the heart-cognition relationships. Cardiac parameters were higher in stage 2 and suspected non-Alzheimer’s pathology groups than controls.
These findings suggested close associations of subclinical cardiac changes with tau pathologies and cognition.

Various subclinical alterations in the left heart related to poorer cognition.
Subclinical cardiac changes related to tau pathologies in cognitively normal adults.
Tau pathologies mediated the heart-cognition relationships.
Subclinical cardiac changes related to the AD continuum, especially to stage 2.
The accumulation of cardiac alterations magnified their damage to the brain.

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This post is Copyright: He‐Ying Hu,
Hao Hu,
Jing Jiang,
Yan‐Lin Bi,
Yan Sun,
Ya‐Nan Ou,
Lan Tan,
Jin‐Tai Yu | April 27, 2024

Wiley: Alzheimer’s & Dementia: Table of Contents