Abstract
BACKGROUND
We investigated the effects of apolipoprotein E (APOE) ε4 and its interactions with sociodemographic characteristics on cognitive measures in South Asians from the Diagnostic Assessment of Dementia for the Longitudinal Aging Study of India (LASI-DAD).
METHODS
Linear regression was used to assess the association between APOE ε4 and global- and domain-specific cognitive function in 2563 participants (mean age 69.6 ± 7.3 years; 53% female). Effect modification by age, sex, and education were explored using interaction terms and subgroup analyses.
RESULTS
APOE ε4 was inversely associated with most cognitive measures (p < 0.05). This association was stronger with advancing age for the Hindi Mental State Examination (HMSE) score (β
ε4×age = −0.44, p = 0.03), orientation (β
ε4×age = −0.07, p = 0.01), and language/fluency (β
ε4×age = −0.07, p = 0.01), as well as in females for memory (β
ε4×male = 0.17, p = 0.02) and language/fluency (β
ε4×male = 0.12, p = 0.03).
DISCUSSION
APOE ε4 is associated with lower cognitive function in South Asians from India, with a more pronounced impact observed in females and older individuals.
Highlights
APOE ε4 carriers had lower global and domain-specific cognitive performance.
Females and older individuals may be more susceptible to ε4 effects.
For most cognitive measures, there was no interaction between ε4 and education.
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This post is Copyright: Yi Zhe Wang,
Wei Zhao,
Priya Moorjani,
Alden L. Gross,
Xiang Zhou,
Aparajit B. Dey,
Jinkook Lee,
Jennifer A. Smith,
Sharon L. R. Kardia | June 19, 2024