We investigated the effect vigorous physical activity (VPA) on the risk of incident mild cognitive impairment (MCI) and probable dementia among individuals with high-risk hypertension.
Baseline self-reported frequency of VPA was categorized into low VPA (<1 session/week), and high VPA (≥1 session/week). We used multivariate Cox regression analysis to examine the association of VPA categories with incident MCI and probable dementia events.
Participants in the high VPA category, compared with low VPA, experienced lower events rates (per 1000 person-years) of MCI (13.9 vs 19.7), probable dementia (6.3 vs 9.0), and MCI/probable dementia (18.5 vs 25.8). In the multivariate Cox regression model, high VPA, compared with low VPA, was associated with lower risk of MCI, probable dementia, and MCI/probable dementia (HR [95% CI]: 0.81 [0.68–0.97], 0.80 [0.63–1.03], and 0.82 [0.70–0.96]), respectively.
This study provides evidence that VPA may preserve cognitive function in high-risk patients with hypertension.

Hypertension is associated with an increased risk of cognitive impairment
Physical activity (PA) is associated with a lower risk of decline in cognition
The effect of ≥1 sessions of vigorous-intensity PA (VPA) per week was assessed
This analysis included SPRINT MIND trial participants with high-risk hypertension
≥1 VPA sessions/week was associated with lower risk of future cognitive impairment

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This post is Copyright: Richard Kazibwe,
Christopher L. Schaich,
Ahmad Imtiaz Muhammad,
Isabella Epiu,
Juliana H. Namutebi,
Parag A. Chevli,
Joseph Kazibwe,
Timothy Hughes,
Rishi R. Rikhi,
Michael D. Shapiro,
Joseph Yeboah | June 6, 2024

Wiley: Alzheimer’s & Dementia: Table of Contents