Abstract
INTRODUCTION
Limbic-predominant age-related TAR DNA-binding protein of 43 kDa encephalopathy neuropathologic change (LATE-NC) staging criteria were updated in 2023. We evaluated this updated staging using National Alzheimer’s Coordinating Center data.
METHODS
We examined associations of LATE-NC stages with cognition and other neuropathologic changes (NCs), and with cognition while accounting for other NCs, using multilevel regression models.
RESULTS
Of 1352 participants, 502 (37%) had LATE-NC (23% stage 1a, 6% stage 1b, 58% stage 2, 13% stage 3). LATE-NC stages were associated with cognition, hippocampal sclerosis of aging (HS-A), Alzheimer’s disease NC (ADNC), Lewy bodies (LBs), and hippocampal atrophy. While stage 1b was associated with cognition and HS-A consistent with other stages, it was not associated with ADNC or LBs. All LATE-NC stages remained significantly associated with worse cognition when accounting for other NCs.
DISCUSSION
The updated LATE-NC staging criteria capture variations in early TDP-43 pathology spread which are consequential for cognition and associations with other NCs.
Highlights
We applied the updated limbic-predominant age-related TAR DNA-binding protein of 43 kDa encephalopathy neuropathologic change (LATE-NC) staging criteria to data from the National Alzheimer’s Coordinating Center.
LATE-NC stage 1b was identified in 22% of participants with stage 1.
In contrast to other LATE-NC stages, stage 1b was not associated with Alzheimer’s disease neuropathologic change (ADNC) or Lewy bodies.
Stages 1a and 1b were significantly associated with dementia and memory impairment.
Stages 1b+ were more strongly tied to dementia than all other neuropathologic changes except high likelihood ADNC.
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This post is Copyright: Davis C. Woodworth,
Katelynn M. Nguyen,
Lorena Sordo,
Kiana A. Scambray,
Elizabeth Head,
Claudia H. Kawas,
María M. Corrada,
Peter T. Nelson,
S. Ahmad Sajjadi | October 1, 2024