Abstract
INTRODUCTION
We investigated heterogeneity in the association between cumulative heat exposure and cognitive decline among older Japanese adults.
METHODS
We analyzed 33,877 adults aged ≥ 65 years from a nationwide cohort (2010–2023) linked with long-term care insurance data. Cumulative heat exposure was indexed using population-weighted wet-bulb globe temperature. Generalized random forests estimated the average and conditional treatment effects. Heterogeneity was decomposed using permutation importance, excess CATE analysis, and UpSet plot analyses.
RESULTS
During a 12-year follow-up, 25.3% developed cognitive decline. Heat exposure increased incidence by 12.17 cases per 1000 person-years (95% confidence interval [CI]: 2.54–21.62). Vulnerability profiles differed by age: among adults aged 65–74 years, multidimensional social and health constraints predominated; among those aged ≥ 75 years, functional decline and relational depletion dominated.
DISCUSSION
Age-specific vulnerability profiles provide a foundation for precision public health: multidomain interventions for adults aged 65–74 years and proactive social outreach for those aged ≥ 75 years.
If you do not see content above, kindly GO TO SOURCE.
Not all publishers encode content in a way that enables republishing at Neuro.vip.
This post is Copyright: | July 14, 2026
Neuro-Dementia