Abstract
INTRODUCTION
Relationships and interplay of an infection burden (IB) and periodontal pathogens or periodontal disease (Pd) markers with Alzheimer’s disease (AD) and all-cause dementia among US adults were examined.
METHODS
Less than or equal to 2997 participants from the National Health and Nutrition Survey III were linked to CMS-Medicare [≥45 years (1988-1994); ≤30 years follow-up].
RESULTS
Hepatitis C (hazard ratio = 3.33, p = 0.004) and herpes simplex virus 2 were strongly associated with greater all-cause dementia risk. Porphyromonas gingivalis and Streptococcus oralis were associated with greater AD risk at higher IB. The red-green periodontal pathogen cluster coupled with higher IB count increased the risk of all-cause dementia among minority racial groups. Pocket probing depth associated with dementia risk at lower IB in the overall sample.
DISCUSSION
Select viruses and bacteria were associated with all-cause and AD dementia, while the IB interacted with Pd markers in relation to these outcomes.
Highlights
Interplay of infection burden (IB) and periodontal disease with dementia was tested.
≤2997 participants from NHANES III were linked to Medicare.
Hepatitis C and herpes simplex virus 2 strongly associated with dementia risk.
Tetanus sero-positivity increased Alzheimer’s disease (AD) risk.
Porphyromonas gingivalis and Streptococcus oralis associated with AD at higher IB.
Red-green periodontal cluster at high IB, increased dementia in racial minorities.
Pocket probing depth associated with dementia risk at lower IB.
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This post is Copyright: May A. Beydoun,
Hind A. Beydoun,
Dawson W. Hedges,
Lance D. Erickson,
Shawn D. Gale,
Jordan Weiss,
Ziad W. El‐Hajj,
Michele K. Evans,
Alan B. Zonderman | August 8, 2024