We examined the efficacy of a multidomain intervention in preventing cognitive decline among Japanese older adults with mild cognitive impairment (MCI).
Participants aged 65-85 years with MCI were randomized into intervention (management of vascular risk factors, exercise, nutritional counseling, and cognitive training) and control groups. The primary outcome was changes in the cognitive composite score over a period of 18 months.
Of 531 participants, 406 completed the trial. The between-group difference in composite score changes was 0.047 (95% CI: −0.029 to 0.124). Secondary analyses indicated positive impacts of interventions on several secondary health outcomes. The interventions appeared to be particularly effective for individuals with high attendance during exercise sessions and those with the apolipoprotein E ε4 allele and elevated plasma glial fibrillary acidic protein levels.
The multidomain intervention showed no efficacy in preventing cognitive decline. Further research on more efficient strategies and suitable target populations is required.

This trial evaluated the efficacy of multidomain intervention in individuals with MCI.
The trial did not show a significant difference in preplanned cognitive outcomes.
Interventions had positive effects on a wide range of secondary health outcomes.
Those with adequate adherence or high risk of dementia benefited from interventions.

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This post is Copyright: Takashi Sakurai,
Taiki Sugimoto,
Hiroyasu Akatsu,
Takehiko Doi,
Yoshinori Fujiwara,
Akihiro Hirakawa,
Fumie Kinoshita,
Masafumi Kuzuya,
Sangyoon Lee,
Nanae Matsumoto,
Koichiro Matsuo,
Makoto Michikawa,
Akinori Nakamura,
Susumu Ogawa,
Rei Otsuka,
Kenji Sato,
Hiroyuki Shimada,
Hiroko Suzuki,
Hiroyuki Suzuki,
Hajime Takechi,
Shinya Takeda,
Kazuaki Uchida,
Hiroyuki Umegaki,
Satomu Wakayama,
Hidenori Arai,
J‐MINT study group | April 22, 2024

Wiley: Alzheimer’s & Dementia: Table of Contents