We investigated the association between white matter hyperintensities (WMH) and regional cortical thickness, amyloid and tau deposition, and synaptic density in the WMH-connected cortex using multimodal images.
We included 107 participants (59 with Alzheimer’s disease [AD]; 27 with mild cognitive impairment; 21 cognitively normal controls) with amyloid beta (Aβ) positivity on amyloid positron emission tomography (PET). The cortex connected to WMH was identified using probabilistic tractography.
We found that WMH connected to the cortex with more severe regional degeneration as measured by cortical thickness, Aβ and tau deposition, and synaptic vesicle glycoprotein 2 A (SV2A) density using 18F-SynVesT-1 PET. In addition, higher ratios of Aβ in the deep WMH-connected versus WMH-unconnected cortex were significantly related to lower cognitive scores. Last, the cortical thickness of WMH-connected cortex reduced more than WMH-unconnected cortex over 12 months.
Our results suggest that WMH may be associated with AD-intrinsic processes of degeneration, in addition to vascular mechanisms.

We studied white matter hyperintensities (WMHs) and WMH-connected cortical changes.
WMHs are associated with more severe regional cortical degeneration.
Findings suggest WMHs may be associated with Alzheimer’s disease–intrinsic processes of degeneration.

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This post is Copyright: Junfang Zhang,
Haijuan Chen,
Jie Wang,
Qi Huang,
Xiaomeng Xu,
Wenjing Wang,
Wei Xu,
Yihui Guan,
Jun Liu,
Joanna M Wardlaw,
Yulei Deng,
Fang Xie,
Binyin Li | April 23, 2024

Wiley: Alzheimer’s & Dementia: Table of Contents