Abstract
INTRODUCTION
Frontotemporal lobar degeneration (FTLD) encompasses behavioral variant frontotemporal dementia (bvFTD), progressive supranuclear palsy, corticobasal syndrome/degeneration, and primary progressive aphasias (PPAs). We cross-validated fluid biomarkers and neuroimaging.
METHODS
Seven fluid biomarkers from cerebrospinal fluid and serum were related to atrophy in 428 participants including these FTLD subtypes, logopenic variant PPA (lvPPA), Alzheimer’s disease (AD), and healthy subjects. Atrophy was assessed by structural magnetic resonance imaging and atlas-based volumetry.
RESULTS
FTLD subtypes, lvPPA, and AD showed specific profiles for neurofilament light chain, phosphorylated heavy chain, tau, phospho-tau, amyloid beta1-42 from serum/cerebrospinal fluid, and brain atrophy. Neurofilaments related to regional atrophy in bvFTD, whereas progranulin was associated with atrophy in semantic variant PPA. Ubiquitin showed no effects.
DISCUSSION
Results specify biomarker and atrophy patterns in FTLD and AD supporting differential diagnosis. They identify neurofilaments and progranulin in interaction with structural imaging as promising candidates for monitoring disease progression and therapy.
Highlights
Study cross-validated neuroimaging and fluid biomarkers in dementia.
Five kinds of frontotemporal lobar degeneration and two variants of Alzheimer’s disease.
Study identifies disease-specific fluid biomarker and atrophy profiles.
Fluid biomarkers and atrophy interact in a disease-specific way.
Neurofilaments and progranulin are proposed as biomarkers for diagnosis and therapy.
If you do not see content above, kindly GO TO SOURCE.
Not all publishers encode content in a way that enables republishing at Neuro.vip.
This post is Copyright: Lea Hüper,
Petra Steinacker,
Maryna Polyakova,
Karsten Mueller,
Jannis Godulla,
Sabine Herzig,
Adrian Danek,
Annerose Engel,
Janine Diehl‐Schmid,
Joseph Classen,
Klaus Fassbender,
Klaus Fliessbach,
Holger Jahn,
Jan Kassubek,
Johannes Kornhuber,
Bernhard Landwehrmeyer,
Martin Lauer,
Hellmuth Obrig,
Patrick Oeckl,
Johannes Prudlo,
Dorothee Saur,
Sarah Anderl‐Straub,
Matthis Synofzik,
Matias Wagner,
Jens Wiltfang,
Juliane Winkelmann,
Alexander E. Volk,
FTLD Consortium Germany,
Hans‐Jürgen Huppertz,
Markus Otto,
Matthias L. Schroeter | June 13, 2024