Abstract
INTRODUCTION
We investigated the association between sleep duration and neuropathologic changes 19 to 40 years later in oldest-old (age 90+) participants of The 90+ Study.
METHODS
Participants self-reported sleep duration and underwent neuropathologic evaluation. We categorized sleep duration as < 7, 7 to 8 = reference, > 8 hours and dichotomized neuropathologic changes as present/absent. We estimated odds ratio (OR) and 95% confidence intervals (CI) using logistic regression.
RESULTS
In 264 participants, mean age at sleep self-report was 69 years, mean age at autopsy was 98 years, and mean interval between sleep self-report and autopsy was 29 years (range: 19–40). Those reporting > 8 hours of sleep had lower likelihood of limbic-predominant age-related TDP-43 encephalopathy neuropathologic change (LATE-NC) inclusions (OR = 0.18; CI = 0.04–0.82) and amyloid beta deposits (OR = 0.34; 95% CI = 0.12–0.94).
DISCUSSION
Long self-reported sleep is associated with lower odds of neurodegenerative neuropathologic changes 19 to 40 years later in the oldest-old, suggesting a potential role of sleep in accumulation of dementia-related neuropathologies.
Highlights
Association of self-reported sleep with non-Alzheimer’s disease neuropathologic changes has not been explored.
Whether sleep duration is related to dementia neuropathologic changes decades later is unclear.
Long self-reported sleep is associated with lower odds of Alzheimer’s disease neuropathologic change 19 to 40 years later in the oldest-old.
Long self-reported sleep is associated with lower odds of limbic-predominant age-related TDP-43 encephalopathy neuropathologic change 19 to 40 years later in the oldest-old.
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This post is Copyright: Zarui A. Melikyan,
Claudia H. Kawas,
Annlia Paganini‐Hill,
Luohua Jiang,
Syed Bukhari,
Thomas J. Montine,
Bryce A. Mander,
María M. Corrada | April 11, 2024