Abstract
BACKGROUND
We sought to characterize the cognitive profile among individuals with mild cognitive impairment with Lewy bodies (MCI-LB) to help guide future clinical criteria.
METHODS
Systematic review and meta-analysis included MCI-LB studies with cognitive data from PubMed, Embase, Web of Science, and PsycINFO (January 1990 to March 2023). MCI-LB scores were compared to controls, MCI due to Alzheimer’s disease (MCI-AD), and dementia with Lewy bodies (DLB) groups with random-effects models.
RESULTS
We included 26 studies and 2823 participants. Across all domains, the MCI-LB group performed worse than controls and better than DLB. Compared to MCI-AD, the MCI-LB group performed worse in attention/processing speed (g = –0.24, 95% confidence interval [CI]: –0.35, –0.12), attention/executive (g = –0.42, 95% CI: –0.56, –0.28); better in verbal immediate recall (g = 0.37; 95% CI: 0.15, 0.59) and delayed memory (g = 0.40; 95% CI: 0.22, 0.58).
DISCUSSION
The cognitive profiles in MCI-LB and MCI-AD are consistent with established profiles in DLB and AD. Neuropsychological assessment may be helpful in differential diagnosis, even in early disease states.
Highlights
We performed a systematic review and meta-analysis for cognition in mild cognitive impairment with Lewy bodies (MCI-LB).
Compared to MCI due to Alzheimer’s disease (MCI-AD), MCI-LB had worse attention, executive function, and processing speed.
Compared to MCI-AD, MCI-LB had better verbal immediate and delayed recall.
The MCI-LB group was worse on all cognitive domains than controls, and better than dementia with Lewy bodies.
Studies used different tests and there is a need for global efforts for harmonization.
If you do not see content above, kindly GO TO SOURCE.
Not all publishers encode content in a way that enables republishing at Neuro.vip.
This post is Copyright: Kathryn A. Wyman‐Chick,
Ece Bayram,
Stephanie Gravett,
Fabrizia D’Antonio,
Federico Rodriguez‐Porcel,
Joseph P. M. Kane,
Tanis J. Ferman,
Barbara A. Olson‐Bullis,
Bradley F. Boeve,
Laura Bonanni,
Daniel Ferreira,
the Alzheimer’s Association International Society to Advance Alzheimer’s Research and Treatment (ISTAART) Lewy Body Dementias Professional Interest Area (LBD PIA) Prodromal Working Group | January 10, 2025