Mild cognitive impairment (MCI) is a prodromal stage of dementia. Understanding the mechanistic changes from healthy aging to MCI is critical for comprehending disease progression and enabling preventative intervention.
Patients with MCI and age-matched controls (CN) were administered cognitive tasks during functional near-infrared spectroscopy (fNIRS) recording, and changes in plasma levels of extracellular vesicles (EVs) were assessed using small-particle flow cytometry.
Neurovascular coupling (NVC) and functional connectivity (FC) were decreased in MCI compared to CN, prominently in the left-dorsolateral prefrontal cortex (LDLPFC). We observed an increased ratio of cerebrovascular endothelial EVs (CEEVs) to total endothelial EVs in patients with MCI compared to CN, correlating with structural MRI small vessel ischemic damage in MCI. LDLPFC NVC, CEEV ratio, and LDLPFC FC had the highest feature importance in the random Forest group classification.
NVC, CEEVs, and FC predict MCI diagnosis, indicating their potential as markers for MCI cerebrovascular pathology.

Neurovascular coupling (NVC) is impaired in mild cognitive impairment (MCI).
Functional connectivity (FC) compensation mechanism is lost in MCI.
Cerebrovascular endothelial extracellular vesicles (CEEVs) are increased in MCI.
CEEV load strongly associates with cerebral small vessel ischemic lesions in MCI.
NVC, CEEVs, and FC predict MCI diagnosis over demographic and comorbidity factors.

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This post is Copyright: Cameron D. Owens,
Camila Bonin Pinto,
Peter Mukli,
Rafal Gulej,
Faddi Saleh Velez,
Sam Detwiler,
Lauren Olay,
Jordan R. Hoffmeister,
Zsofia Szarvas,
Mihaly Muranyi,
Anna Peterfi,
Ana Clara da C. Pinaffi‐Langley,
Cheryl Adams,
Jason Sharps,
Zalan Kaposzta,
Calin I. Prodan,
Angelia C. Kirkpatrick,
Stefano Tarantini,
Anna Csiszar,
Zoltan Ungvari,
Ann L. Olson,
Guangpu Li,
Priya Balasubramanian,
Veronica Galvan,
Andrew Bauer,
Zachary A. Smith,
Tarun W. Dasari,
Shawn Whitehead,
Manoj R. Medapti,
Fanny M. Elahi,
Aikaterini Thanou,
Andriy Yabluchanskiy | July 3, 2024

Wiley: Alzheimer’s & Dementia: Table of Contents