Abstract
INTRODUCTION
Bumetanide, a loop diuretic, was identified as a candidate drug for repurposing for Alzheimer’s disease (AD) based on its effects on transcriptomic apolipoprotein E signatures. Cross-sectional analyses of electronic health records suggest that bumetanide is associated with decreased prevalence of AD; however, temporality between bumetanide exposure and AD development has not been established.
METHODS
We evaluated Medicare claims data using Cox proportional hazards regression to evaluate the association between time-dependent use of bumetanide and time to first AD diagnosis while controlling for patient characteristics. Multiple sensitivity analyses were conducted to test the robustness of the findings.
RESULTS
We sampled 833,561 Medicare beneficiaries, 60.8% female, with mean (standard deviation) age of 70.4 (12). Bumetanide use was not significantly associated with AD risk (hazard ratio 1.05; 95% confidence interval, 0.99–1.10).
DISCUSSION
Using a nationwide dataset and a retrospective cohort study design, we were not able to identify a time-dependent effect of bumetanide lowering AD risk.
Highlights
Bumetanide was identified as a candidate for repurposing for Alzheimer’s disease (AD).
We evaluated the association between bumetanide use and risk of AD.
We used Medicare data and accounted for duration of bumetanide use.
Bumetanide use was not significantly associated with risk of AD.
If you do not see content above, kindly GO TO SOURCE.
Not all publishers encode content in a way that enables republishing at Neuro.vip.
This post is Copyright: Jasmine Morales,
Nico Gabriel,
Loki Natarajan,
Andrea Z. LaCroix,
Aladdin H. Shadyab,
Ronghui Xu,
James Silverman,
Howard H. Feldman,
Inmaculada Hernandez,
for the Powder for Pennies Collaboration,
Vahan Aslanyan,
Anne Bang,
Elizabeth Bevins,
Gene L. Bowman,
Ben Boyarko,
Xu Chen,
Claire D. Clelland,
Hiroko H. Dodge,
January Durant,
Steve D. Edland,
A. Carol Evans,
Doug R. Galasko,
William H. Gerwick,
Barry D. Greenberg,
Michelle Herman,
Tatiana Herold,
Vivian Hook,
Diane M. Jacobs,
Jeffrey Kaye,
Doo Yeon Kim,
Edward H. Koo,
Ken S. Kosik,
Gabriel Léger,
Jody‐Lynn Lupo,
Karen Messer,
Jeremiah D. Momper,
Haakon B. Nygaard,
Judy Pa,
Luisa Quinti,
Carolyn Revta,
Jessica E. Rexach,
Stacey J. Sukoff Rizzo,
Kevin D. Rynearson,
Lon Schneider,
Barbara Slusher,
Rudolph E. Tanzi,
Paul R. Territo,
Jennifer S. Yokoyama | June 22, 2024