Abstract
INTRODUCTION
Blood-based biomarkers are a cost-effective and minimally invasive method for diagnosing the early and preclinical stages of amyloid positivity (AP). Our study aims to investigate our novel immunoprecipitation-immunoassay (IP-IA) as a test for predicting cognitive decline.
METHODS
We measured levels of amyloid beta (Aβ)X-40 and AβX-42 in immunoprecipitated eluates from the DELCODE cohort. Receiver-operating characteristic (ROC) curves, regression analyses, and Cox proportional hazard regression models were constructed to predict AP by Aβ42/40 classification in cerebrospinal fluid (CSF) and conversion to mild cognitive impairment (MCI) or dementia.
RESULTS
We detected a significant correlation between AßX-42/X-40 in plasma and CSF (r = 0.473). Mixed-modeling analysis revealed a substantial prediction of AßX-42/X-40 with an area under the curve (AUC) of 0.81 for AP (sensitivity: 0.79, specificity: 0.74, positive predictive value [PPV]: 0.71, negative predictive value [NPV]: 0.81). In addition, lower AβX-42/X-40 ratios were associated with negative PACC5 slopes, suggesting cognitive decline.
DISCUSSION
Our results suggest that assessing the plasma AβX-42/X-40 ratio via our semiautomated IP-IA is a promising biomarker when examining patients with early or preclinical AD.
Highlights
New plasma Aβ42/Aβ40 measurement using immunoprecipitation–immunoassay
Plasma Aβ42/Aβ40 associated with longitudinal cognitive decline
Promising biomarker to detect subjective cognitive decline at-risk for brain amyloid positivity
If you do not see content above, kindly GO TO SOURCE.
Not all publishers encode content in a way that enables republishing at Neuro.vip.
This post is Copyright: Jonathan Vogelgsang,
Niels Hansen,
Melina Stark,
Michael Wagner,
Hans Klafki,
Barbara Marcos Morgado,
Anke Jahn‐Brodmann,
Björn Schott,
Hermann Esselmann,
Chris Bauer,
Johannes Schuchhardt,
Luca Kleineidam,
Steffen Wolfsgruber,
Oliver Peters,
Luisa‐Sophie Schneider,
Xiao Wang,
Felix Menne,
Josef Priller,
Eike Spruth,
Slawek Altenstein,
Andrea Lohse,
Anja Schneider,
Klaus Fliessbach,
Ina Vogt,
Claudia Bartels,
Frank Jessen,
Ayda Rostamzadeh,
Emrah Duezel,
Wenzel Glanz,
Enise Incesoy,
Michaela Butryn,
Katharina Buerger,
Daniel Janowitz,
Michael Ewers,
Robert Perneczky,
Boris Rauchmann,
Selim Guersel,
Stefan Teipel,
Ingo Kilimann,
Doreen Goerss,
Christoph Laske,
Matthias Munk,
Carolin Sanzenbacher,
Annika Spottke,
Nina Roy‐Kluth,
Michael Heneka,
Frederic Brosseron,
Alfredo Ramierez,
Matthias Schmid,
Jens Wiltfang | June 28, 2024