Abstract
INTRODUCTION
Many individuals change their smoking habits after cancer diagnosis. We aimed to evaluate the association of post-diagnosis smoking habit change with incident dementia in cancer survivors.
METHODS
We identified 558,127 individuals who were diagnosed with cancer at age ≥ 20 and survived for ≥ 3 years. Participants were classified into four groups: (1) sustained non-smokers, (2) initiators/relapsers, (3) quitters, and (4) continuing smokers. Dementia risk in each group was assessed using a cause-specific Cox model.
RESULTS
After cancer diagnosis, 2.3% of pre-diagnosis non-smokers initiated/relapsed into smoking, while 51.7% of pre-diagnosis smokers quit smoking. Compared to sustained non-smokers, multivariable-adjusted risk of dementia was 29% higher among initiators/relapsers, 11% higher among quitters, and 31% higher among continuing smokers. Compared to continuing smokers, the risk was 15% lower among quitters.
DISCUSSION
In cancer survivors, smoking initiation/relapse was associated with increased risk of dementia, whereas smoking cessation was associated with decreased risk of dementia.
Highlights
Approximately half of pre-diagnosis smokers quit smoking after a cancer diagnosis.
Smoking cessation was associated with a 15% reduced risk of dementia.
More than 2% of pre-diagnosis non-smokers initiated or relapsed into smoking after a cancer diagnosis.
Smoking initiation/relapse was associated with a 29% elevated risk of dementia.
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This post is Copyright: Hyeok‐Hee Lee,
Jaeun Ahn,
Changchuan Jiang,
Young‐gun Lee,
Hyeon Chang Kim,
Hokyou Lee | August 9, 2024