Abstract
INTRODUCTION
Long-term blood pressure variability (BPV) and plasma neurofilament light (pNfL) have been identified as potential biomarkers for Alzheimer’s disease (AD) and cerebral small vessel disease (CSVD). However, the relationship between BPV, pNfL, and their association with the comorbidity of AD and CSVD remains unknown.
METHODS
Participants with normal cognition and mild cognitive impairment from the Alzheimer’s Disease Neuroimaging Initiative study were included in the data analysis. Linear mixed-effects regression models and causal mediation analyses were conducted to investigate the relationship among BPV, pNfL, comorbidity-related brain structural changes (hippocampal atrophy and white matter hyperintensities [WMH]), and cognitive function.
RESULTS
BPV was associated with pNfL, volumes of hippocampus and WMH, and cognition. pNfL mediated the effects of BPV on brain structural changes and cognition.
DISCUSSION
Our findings suggest a potential role of BPV and pNfL in the mechanism of comorbidity between AD and CSVD, underscoring the importance of BPV intervention in the general population.
Highlights
Individuals with both Alzheimer’s disease (AD) and cerebral small vessel disease (CSVD) pathologies had elevated blood pressure variability (BPV) and plasma neurofilament light (pNfL).
The association between different components of BPV and brain structural changes may vary.
BPV was associated with pNfL levels independent of average blood pressure.
pNfL mediated the effects of BPV on comorbidity-related brain structural changes and cognitive performance.
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This post is Copyright: Qin Li,
Shu Su,
Yuxue Feng,
Meng Jia,
Jiehong Zhan,
Zixuan Liao,
Jiayu Li,
Xiaofeng Li,
for the Alzheimer’s Disease Neuroimaging Initiative | June 19, 2024