Abstract
INTRODUCTION
Primary age-related tauopathy (PART), often regarded as a minimally symptomatic pathology of old age, lacks comprehensive cohorts across various age groups.
METHODS
We examined PART prevalence and clinicopathologic features in 1589 forensic autopsy cases (≥40 years old, mean age ± SD 70.2 ± 14.2 years).
RESULTS
PART cases meeting criteria for argyrophilic grain diseases (AGD) were AGD+PART (n = 181). The remaining PART cases (n = 719, 45.2%) were classified as comorbid conditions (PART-C, n = 90) or no comorbid conditions (pure PART, n = 629). Compared to controls (n = 208), Alzheimer’s disease (n = 133), and AGD+PART, PART prevalence peaked in the individuals in their 60s (65.5%) and declined in the 80s (21.5%). No significant clinical background differences were found (excluding controls). However, PART-C in patients inclusive of age 80 had a higher suicide rate than pure PART (p < 0.05), and AGD+PART showed more dementia (p < 0.01) and suicide (p < 0.05) than pure PART.
DISCUSSION
Our results advocate a reevaluation of the PART concept and its diagnostic criteria.
Highlights
We investigated 1589 forensic autopsy cases to investigate the features of primary age-related tauopathy (PART).
PART peaked in people in their 60s in our study.
Many PART cases over 80s had comorbid pathologies in addition to neurofibrillary tangles pathology.
Argyrophilic grain disease and Lewy pathology significantly affected dementia and suicide rates in PART.
Our results suggest that the diagnostic criteria of PART need to be reconsidered.
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This post is Copyright: Koji Yoshida,
Yukiko Hata,
Shojiro Ichimata,
Ryo Tanaka,
Naoki Nishida | June 28, 2024