Abstract
INTRODUCTION
Subjective cognitive decline (SCD) may be an early marker of Alzheimer’s disease (AD) pathology. Until recently, it was impossible to measure biomarkers specific for α-synuclein pathology; therefore, its association with subjective reports of cognitive decline is unknown.
METHODS
Alzheimer’s Disease Neuroimaging Initiative participants without dementia (n = 918) were classified as positive or negative for amyloid beta (Aβ+ or Aβ−) and α-synuclein (α-syn+ or α-syn−) biomarkers. Self- and study partner–reported cognitive decline was measured with the Everyday Cognition (ECog) questionnaire.
RESULTS
Per self-report, Aβ+/α-syn+ had the greatest cognitive decline. Aβ−/α-syn+ did not differ from Aβ−/α-syn− across ECog scores. Study partner–reported results had a similar pattern, but Aβ+/α-syn− and Aβ+/α-syn+ did not differ across ECog scores. Mild cognitive impairment classification moderated the study partner–reported memory score.
DISCUSSION
While α-syn+ alone did not increase subjective reports of cognitive decline, Aβ+/α-syn+ had the most self- and study partner–rated cognitive decline. Therefore, the presence of multiple pathologies was associated with greater SCD.
Highlights
Cerebrospinal fluid α-synuclein (α-syn) seed amplification assay was used to determine α-syn positivity.
Amyloid beta (Aβ)−/α-syn−, Aβ−/α-syn+, Aβ+/α-syn−, and Aβ+/α-syn+ biomarker groups were created.
Aβ+/α-syn+ had greater subjective cognitive decline (SCD) than the other biomarker groups.
Aβ−/α-syn+ did not differ from Aβ−/α-syn− across self- or study–partner reported SCD scores.
Study partner–reported subjective memory results were largely driven by participants with mild cognitive impairment.
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This post is Copyright: Kelsey R. Thomas,
Katherine J. Bangen,
Lindsay J. Rotblatt,
Alexandra J. Weigand,
Lauren Edwards,
Duygu Tosun,
Douglas Galasko,
for the Alzheimer’s Disease Neuroimaging Initiative | September 23, 2024