The effects of sleep–wake behavior on perceived fatigability and cognitive abilities when performing daily activities have not been investigated across levels of cognitive reserve (CR).
CR Index Questionnaire (CRIq) data were collected and subjected to moderated mediation analysis.
In amnestic mild cognitive impairment (aMCI; n = 41), CR moderated sleep-related impairments (SRIs), and fatigability at low CR (CRIq < 105.8, p = 0.004) and mean CR (CRIq = 126.9, p = 0.03) but not high CR (CRIq > 145.9, p = 0.65) levels. SRI affected cognitive abilities mediated by fatigability at low CR (p < 0.001) and mean CR (p = 0.003) levels. In healthy controls (n = 13), SRI in fatigability did not alter cognitive abilities across CR levels; controls had higher leisure scores than patients with aMCI (p = 0.003, effect size = 0.93).
SRI can amplify impaired cognitive abilities through exacerbation of fatigability in patients with aMCI with below-mean CR. Therefore, improving sleep–wake regulation and leisure activities may protect against fatigability and cognitive decline.

Clinical fatigue and fatigability cannot be alleviated by rest.
Clinical fatigability disrupts daily activities during preclinical Alzheimer’s.
High cognitive reserve mitigates sleep–wake disturbance effects.
High cognitive reserve attenuates clinical fatigability effects on daily functioning.
Untreated obstructive sleep apnea potentiates Alzheimer’s pathology in the brain.

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This post is Copyright: Nancy Kerner,
Terry E. Goldberg,
Hannah R. Cohen,
Julia G. Phillips,
Daniel E. Cohen,
Howard Andrews,
Gregory Pelton,
Davangere P. Devanand | May 1, 2024

Wiley: Alzheimer’s & Dementia: Table of Contents