Abstract
INTRODUCTION
There remains an urgent need to identify preclinical pathophysiological mechanisms of Alzheimer’s disease (AD) development in high-risk, racially diverse populations. We explored the relationship between cerebrospinal fluid (CSF) markers of vascular injury and neuroinflammation with AD biomarkers in middle-aged Black/African American (B/AA) and non-Hispanic White (NHW) participants.
METHODS
Adults (45–65 years) with a parental history of AD were enrolled (n = 82). CSF and blood biomarkers were collected at baseline and year 2.
RESULTS
CSF total tau (t-tau), phosphorylated tau (p-tau), and amyloid beta (Aβ)40 were elevated at year 2 compared to baseline. CSF soluble platelet-derived growth factor receptor β (sPDGFRβ) levels, a marker of pericyte injury, correlated positively with t-tau, p-tau, Aβ40 markers of vascular injury, and cytokines at baseline and year 2. CSF sPDGFRβ and tau were significantly lower in B/AA than NHW.
DISCUSSION
Vascular dysfunction and neuroinflammation may precede cognitive decline and disease pathology in the very early preclinical stages of AD, and there are race-related differences in these relationships.
Highlights
Cerebrospinal fluid (CSF) Alzheimer’s disease (AD) biomarkers changed over 2 years in high-risk middle-aged adults.
Markers of vascular dysfunction were associated with the CSF biomarkers amyloid beta and tau.
AD biomarkers were lower in Black compared to non-Hispanic White individuals.
Markers of vascular dysfunction were lower among Black individuals.
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This post is Copyright: Brittany Butts,
Hanfeng Huang,
William T. Hu,
Patrick Gavin Kehoe,
James Scott Miners,
Danielle D. Verble,
Henrik Zetterberg,
Liping Zhao,
Lynn Marie Trotti,
Karima Benameur,
Laura M. Scorr,
Whitney Wharton | February 22, 2024