Abstract
INTRODUCTION
We assessed whether macro- and/or micro-structural white matter properties are associated with cognitive resilience to Alzheimer’s disease pathology years prior to clinical onset.
METHODS
We examined whether global efficiency, an indicator of communication efficiency in brain networks, and diffusion measurements within the limbic network and default mode network moderate the association between amyloid-β/tau pathology and cognitive decline. We also investigated whether demographic and health/risk factors are associated with white matter properties.
RESULTS
Higher global efficiency of the limbic network, as well as free-water corrected diffusion measures within the tracts of both networks, attenuated the impact of tau pathology on memory decline. Education, age, sex, white matter hyperintensities, and vascular risk factors were associated with white matter properties of both networks.
DISCUSSION
White matter can influence cognitive resilience against tau pathology, and promoting education and vascular health may enhance optimal white matter properties.
Highlights
Aβ and tau were associated with longitudinal memory change over ∼7.5 years.
White matter properties attenuated the impact of tau pathology on memory change.
Health/risk factors were associated with white matter properties.
If you do not see content above, kindly GO TO SOURCE.
Not all publishers encode content in a way that enables republishing at Neuro.vip.
This post is Copyright: Ting Qiu,
Zhen‐Qi Liu,
François Rheault,
Jon Haitz Legarreta,
Alex Valcourt Caron,
Frédéric St‐Onge,
Cherie Strikwerda‐Brown,
Amelie Metz,
Mahsa Dadar,
Jean‐Paul Soucy,
Alexa Pichet Binette,
R. Nathan Spreng,
Maxime Descoteaux,
Sylvia Villeneuve,
for the PREVENT‐AD Research Group | April 2, 2024