Abstract
BACKGROUND
We assessed the relationship of liver fibrosis score with incident dementia in a large, national sample.
METHODS
For this retrospective cohort study, data of dementia-free individuals aged 40-69 years were derived from electronic records of the largest healthcare provider in Israel. The association between liver fibrosis score (FIB-4), assessed from routine laboratory measurements, and incident dementia was explored through multivariate cox regression models.
RESULTS
Of the total sample (N = 826,578, mean age 55 ± 8 years at baseline), 636,967 (77%) had no fibrosis, 180,114 (21.8%) had inconclusive fibrosis status and 9497 (1.2%) had high risk for advanced fibrosis. Over a median follow-up of 17 years, 41,089 dementia cases were recorded. Inconclusive liver fibrosis and advanced fibrosis were associated with increased dementia risk (HR = 1.09, 95%CI: 1.07–1.11 and HR = 1.18, 95%CI: 1.10–1.27, respectively). This association remained robust through seven sensitivity analyses.
CONCLUSIONS
Liver fibrosis assessed through a serum-based algorithm may serve as a risk factor for dementia in the general population.
Highlights
Liver fibrosis may predict dementia diagnosis in the general population.
Inconclusive liver fibrosis was associated with 9% increased dementia risk.
Advanced liver fibrosis was associated with 18% increased dementia risk.
Findings remained robust in sensitivity analyses and after adjustments.
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This post is Copyright: Galit Weinstein,
Yochai Schonmann,
Hanny Yeshua,
Shira Zelber‐Sagi | July 1, 2024