Abstract
INTRODUCTION
The role of information processing speed (IPS) on relationships between episodic memory (EM) and central remodeling features in amnestic mild cognitive impairment (aMCI) was investigated.
METHODS
Neuropsychological evaluations and multimodal magnetic resonance imaging were performed on 48 patients diagnosed with aMCI and 50 healthy controls (HC). Moderation models explored the moderating effect of IPS on associations between EM and imaging features at single-region, connectivity, and network levels.
RESULTS
IPS significantly enhanced the positive correlations between recall and cortical thickness of left inferior temporal gyrus. IPS also notably amplified negative correlations between recognition and functional connectivity (FC) of left inferior parietal lobe and right occipital, as well as between recall/recognition and nodal clustering coefficient of left anterior cingulate cortex.
DISCUSSION
IPS functioned as a moderator of associations between recall and neuroimaging metrics at the “single region-connectivity-network” level, providing new insights for cognitive rehabilitation in aMCI patients.
Highlights
aMCI patients exhibited brain functional and structural remodeling alterations.
IPS moderated relations between episodic memory and brain remodeling metrics.
Therapy targeted at IPS can be considered for improving episodic memory in aMCI.
If you do not see content above, kindly GO TO SOURCE.
Not all publishers encode content in a way that enables republishing at Neuro.vip.
This post is Copyright: Jie Ma,
Juan‐Juan Lu,
Jia‐Jia Wu,
Yun‐Ting Xiang,
Mou‐Xiong Zheng,
Xu‐Yun Hua,
Jian‐Guang Xu | August 28, 2024