Abstract
INTRODUCTION
African Americans (AAs) face a higher risk of Alzheimer’s disease and related dementias (ADRD) than European Americans (EUs), yet the utility of polygenic risk scores (PRS) in AAs remains underexplored.
METHODS
A standardized dementia PRS was evaluated in the Chicago Health and Aging Project (n = 4336; 61% AA) for associations with ADRD and cognitive trajectories over 8.4 years.
RESULTS
PRS predicted ADRD more strongly in EUs (c-index 0.86) than AAs (0.77); however, it conferred higher risk in AAs (hazard ratio [HR] = 1.36, 95% confidence interval [CI]: 1.04–1.78) compared to EU (HR = 1.13, 95% CI: 0.88–1.44). The PRS remained predictive among AAs after apolipoprotein E (APOE) ε4 adjustment (HR = 1.53, 95% CI: 1.03–2.27). Higher PRS associated with lower baseline cognition and faster decline (p < 0.05).
DISCUSSION
PRS conferred greater ADRD risk in AAs and comparable rates of cognitive decline, despite stronger discrimination in EUs, adding to the limited knowledge of genetic contributions to ADRD risk among AAs beyond APOE ε4 alleles.
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This post is Copyright: | August 5, 2026
Neuro-Dementia