Abstract
INTRODUCTION
Accelerated long-term forgetting (LTF) might be an early marker of subtle memory changes in older adults at risk for Alzheimer’s disease (AD). We leveraged remote, multi-day digital testing to characterize LTF in older adults and investigated its association with initial learning and AD imaging biomarkers.
METHODS
One hundred four cognitively unimpaired older adults completed a face–name memory task for seven consecutive days and were asked to recognize face–name pairs 1 week later. LTF was computed as the number of correctly identified stimuli divided by a participant’s maximum performance during learning.
RESULTS
Better learning was associated with less LTF (β = 0.52, 95% confidence interval [CI]:0.34–0.71, p < 0.001). Accelerated LTF was associated with cortical thinning in AD-signature regions (β = 0.33, 95% CI: 0.13–0.52, p = 0.001), but associations with regional tau were more subtle.
DISCUSSION
Remote, multi-day testing may facilitate the assessment of LTF as an early cognitive marker of preclinical AD, but further replication is needed.
Highlights
Using digital, remote assessments, we evaluated long-term forgetting in cognitively unimpaired older adults.
We found a potential association between long-term forgetting and tau in Alzheimer’s disease (AD)–related regions.
Assessing long-term forgetting may facilitate early detection of AD-related cognitive decline.
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This post is Copyright: Cassidy P. Molinare,
Daniel Soberanes,
Mark Dubbelman,
Stephanie Hsieh,
Keith A. Johnson,
Dorene M. Rentz,
Reisa A. Sperling,
Gad A. Marshall,
Rebecca E. Amariglio,
Kathryn V. Papp,
Roos J. Jutten | March 20, 2025