Two publications in JNNP explore the potential utility of therapies with differing mechanisms of action for the treatment of chronic inflammatory demyelinating polyradiculoneuropathy (CIDP). Querol et al evaluate the neonatal Fc receptor blocker rozanolixizumab, while Doneddu et al study the anti-CD20 therapeutic monoclonal rituximab.1 2 These agents, respectively, lower serum IgG levels or primarily target the preterminal B-cell lineage. In a disease where a major standard of care is a highly expensive, derived blood product with often precarious availability, which is incompletely effective, requires regular repeated infusions and does not induce long-term remission, such studies are undoubtedly welcome. Nevertheless, both further highlight the tribulations of designing and running trials in CIDP and the intricacies of interpreting and contextualising the results. CIDP, certainly as defined by the 2010 EFNS/PNS criteria,3 is pathogenically diverse. Current treatment regimens are highly variable. Immunological disease activity is disconnected…
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This post is Copyright: Rinaldi, S. | August 16, 2024