Nature Neuroscience, Published online: 11 November 2025; doi:10.1038/s41593-025-02094-yUsing a mouse model enabling an inducible ‘switch’, Golden et al. show that an astrocyte-specific replacement of the Alzheimer’s risk gene APOE4 with protective APOE2 alters metabolism and gene expression, reducing amyloid pathology and gliosis.
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This post is Copyright: | November 11, 2025
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