Nature Neuroscience, Published online: 20 March 2025; doi:10.1038/s41593-025-01925-2The nervous system can drive the initiation, growth, spread, and therapy resistance of cancer, and cancer can manipulate the nervous system in ways that further support disease progression. Tumors growing within the brain or elsewhere in the body connect with neuronal networks in circuit-specific manners, via neuron-to-cancer synaptic interactions and paracrine crosstalk. Moreover, neural factors govern critical components of the tumor environment, such as the immune system, and cancer can use neural mechanisms in a malignant cell-intrinsic manner. Here we provide a personal view on the burgeoning field of cancer neuroscience and highlight the need to approach cancer research from a neuroscience perspective — together with neuroscientists.
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This post is Copyright: Michelle Monje | March 20, 2025
Nature Neuroscience